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KMID : 0861020130280020061
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Korea Journal of Herbology
2013 Volume.28 No. 2 p.61 ~ p.65
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Single Oral Dose Toxicity Test of Fermented Samchulgeonbi-tang Extract in ICR mice
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정영필:Jung Young-Pil
임남희:Yim Nam-Hui/김애영:Kim Ae-yung/황윤환:Hwang Yun-Hwan/박화용:Park Hwa-yong/마진열:Ma Jin-Yeul
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Abstract
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Objectives : Samchulgeonbi-tang (shenzhujianpi-tang) has been prescribed as one of traditional herbal medicine
for treatment of stomach diseases since ancient time in Korea. Samchulgeonbi-tang extract was fermented by
Lactobacillus spp. for improving the effect. However, the toxicity and safety of fermented Samchulgeonbi-tang
(FS) extract were not confirmed. Therefore, this study was performed to evaluate the acute toxicity and safety
of FS extract.
Methods : To evaluate the acute toxicity and safety of FS extract, several doses of FS extract, 0, 500, 1000 and
2000 ㎎/㎏, were orally administered to 20 male and 20 female ICR mice, respectively. After treatment with FS
extract, we observed mortality, general toxicity, behavior and change of body weight for the 14 days. After 14
days of oral administration, all mice were sacrificed and hematological parameters were analyzed from blood
serum.
Results : In present study, the toxic signs such as mortality or abnormal behaviors by FS extract were not
observed. There are no significant differences between FS-treated group and control group in body weight, organ
weights, and hematological parameters.
Conclusions : The remarkable adverse effects by FS extract were not observed in ICR mice. Also, any death was
not occurred at all treated FS doses, 500, 1000 and 2000 ㎎/㎏. Therefore, the approximate lethal dose (ALD) of
FS extract may be more than 2000 ㎎/㎏.
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KEYWORD
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amchulgeonbi-tang (shenzhujianpi-tang), Fermented Samchulgeonbi-tang (FS), Acute toxicity, Safety, ALD
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